Venom Genomics and Proteomics by P. Gopalakrishnakone & Juan J. Calvete

Author:P. Gopalakrishnakone & Juan J. Calvete
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

Conclusion

Understanding the structure and the mode(s) of action of the SVMPs has long been the focus of venom studies due to the important role of these enzymes in the pathophysiology of envenomation. In spite of the decades of research conducted in the characterization of SVMP structure and function, there are still numerous unanswered questions, some of which we know and certainly some as yet to be asked. As new technologies become available in conjunction with the rich databases being generated on these toxins as well as others, we are optimistic that a more complete understanding of SVMP activities in vitro and more importantly in vivo will be gained. Furthermore, novel approaches for understanding SVMP activity in conjunction with other bioactive toxins in the venoms must be developed in order to have a complete system-based understanding of envenomation which will in turn hopefully lead to novel modes of therapeutic intervention.

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